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Researchers of the UCAM, the Aesthetic Dermatological Center of Alicante and the University Hospital of the Vinalopó in Elche (Alicante) intend its healing by modifying the intestinal flora.
The prestigious scientific journal Journal of the American Medical Association (JAMA), which has one of the highest impact rates worldwide, publishes the research project that has led to these results, and which is part of the development of a PhD industrial between the UCAM and the Aesthetic Dermatological Center of Alicante.
Dr. Vicente Navarro, leader of the Research Group 'MiBioPath' of the UCAM and the group of researchers of the Vinalopó hospital managed by the Ribera Salud Group, considers: "This is a great find, although there is a long way to go. We can know the relationship of some intestinal disorders with certain inflammatory diseases Until 4 or 5 years ago it was impossible to establish this relationship, since it was technically impossible to analyze all the microbes that are in the feces, despite knowing that there were patients who had problems gastrointestinal symptoms coinciding with outbreaks of the disease ".
The research, which has had special media coverage in the United States, shows how the modification of the microorganisms located in the intestine of patients with Atopic Dermatitis, by using a mixture of probiotics, causes an 82% improvement in the Index that measures the activity of the disease (SCORAD).
This percentage of response is greater than 24% obtained in the group of control patients who received the usual treatment of corticosteroids applied to skin lesions.
Probiotics modify, normalize the intestinal flora and change the evolution of the disease.
The pre-clinical analyzes in laboratories with models of Drosophila, C. Elegans (helminths) and rats, showed how certain probiotics have anti-inflammatory and immunomodulatory capacity.
With these findings, the researchers designed a combination of non-pathogenic bacteria (probiotics) that were administered orally to the patients included in this study, who were recruited at the Aesthetic Dermatological Center of Alicante, through the protocol established by Dr. Ramírez, Professor of Dermatology at the UCAM.
This action of introducing a high number of beneficial bacteria in the patients, reduced the presence of other harmful bacteria, which produced an improvement of the dermatitis.
"When you introduce so many beneficial bacteria into the body, those that are harmful are eliminated," clarifies Dr. Navarro.
There are previous studies that show that, by modifying the intestinal flora of patients with Atopic Dermatitis, the disease improves.
However, none of them has achieved the success rates obtained in this trial.
Researchers say that now they must continue advancing in this same line to know why this improvement occurs and the effects that these bacteria produce on the immune system against the disease.
"The difference between a probiotic and a medication is that, currently, the first one knows the final effect but not the mechanism of action and that, precisely, is what we are finding out now," explains the principal investigator of the study.
Antibiotics kill both beneficial and harmful bacteria, sometimes they are not the best option
Certain diseases whose origin is currently unknown, such as Psoriasis, could be caused by bacteria.
9 out of 10 cells in the human body are bacteria that are involved in their functioning and are known, as a whole, as a microbiome.
Therefore, this group of experts has decided to open new lines of research to study the remains of bacteria circulating in the blood of patients with Psoriasis, expanding the team working with the American food company Biopolis / ADM, based in Valencia, and the pharmaceutical company Korott, located in Alcoy.
Source: UCAM
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